If you can accept not the straightest route from Europe to Panama check out this bargain deal from Prague to Panama City based on Turkish Airlines. Flights with a layover in Istanbul and an additional stop in Bogota (outbound only) are available from just €378! Moreover based fare includes generous 2x23kg of checked-in luggage allowance. This is also including all taxes, meals and handbag. Great availability throughout the whole year 2020. This is an amazing deal for anyone who can easily reach Prague!
Turkish Airlines deal is available from February to June and September to the beginning of December 2020. Book this deal by the 31st of March.
Prague – Panama City from €409 (Book with the airline)
Booking sample of cheap full-service flights from Prague to Panama from €378 incl 2x23kg bags! Outbound from Czechia to Panama City on the 9th of March. Inbound from Central America back to Prague via Istanbul on the 24th of March 2020.